Leuprolide acetate depot injection (Fosti-sure)

Leuprolide acetate depot injection

If you’re undergoing fertility treatment, coping with endometriosis, or searching for alleviation from uterine fibroids, your physician can also suggest FOSTI-SURE DEPOT, a Leuprolide acetate depot injection synthetic by way of FertileSurePharma. This lengthy-appearing hormonal injection plays a key role in regulating reproductive hormones and getting ready your body for highest quality remedy consequences.
Whether you’re getting ready for IVF, controlling pelvic ache, or lowering fibroid size, FOSTI-SURE DEPOT allows suppress herbal hormone cycles quickly to enhance medical and reproductive effects.

What Is FOSTI-SURE DEPOT (Leuprolide Acetate Depot 3.75mg)?

FOSTI-SURE DEPOT is a gonadotropin-freeing hormone (GnRH) agonist containing Leuprolide acetate depot injection, a synthetic hormone that acts to your pituitary gland. It comes in a depot system, because of this it releases the drugs slowly over 1 month, making sure regular hormone suppression.

It is primarily used to:
Temporarily shut down natural hormone production (FSH & LH)

Suppress ovulation or menstruation in conditions like endometriosis

Prepare the ovaries and uterus for IVF or ICSI treatment

Help shrink uterine fibroids by lowering estrogen levels

Treat hormone-sensitive conditions like adenomyosis or PCOS

Uses of Leuprolide acetate depot injection

Your doctor may prescribe FOSTI-SURE DEPOT in several reproductive health and gynecology scenarios:

1. In-Vitro Fertilization (IVF) Protocols

In IVF, Leuprolide acetate depot injection is used in long or ultra-long protocols to prevent premature ovulation and allow controlled ovarian stimulation. This improves egg quality, synchronization, and fertilization success.

2. Endometriosis Treatment

By reducing estrogen, this injection helps shrink endometrial implants, easing pelvic pain, heavy bleeding, and inflammation.

3. Uterine Fibroids

Leuprolide acetate depot injection can temporarily shrink fibroids by reducing hormone levels, especially before surgery like myomectomy.

4. Adenomyosis

In cases of adenomyosis, Leuprolide helps reduce symptoms like dysmenorrhea, heavy periods, and uterine swelling.

5. PCOS Pre-Treatment

In certain PCOS patients with high LH levels, suppressing hormones using GnRH agonists like Leuprolide helps restore hormonal balance before ovulation induction.

How Does Leuprolide acetate depot injection Work?

Leuprolide acetate depot injection acts on the pituitary gland in your brain to initially stimulate and then shut down production of:
FSH (Follicle Stimulating Hormone)

LH (Luteinizing Hormone)

This process, called downregulation, leads to a temporary “menopause-like” state by lowering estrogen levels. This effect can:
Prevent premature egg release in IVF cycles

Starve endometrial tissue and fibroids of estrogen

Reduce inflammation and pain

The depot formulation maintains consistent hormone suppression over 28–30 days with a single injection.

How and When to Use Leuprolide acetate depot injection

Your fertility or gynecology specialist will guide you on the exact timing and schedule.

Administration:

Dose: 3.75mg Leuprolide acetate

Route: Intramuscular (IM) injection

Frequency: Once every 28 days

Duration: 1–6 months depending on treatment purpose

Often used before starting IVF stimulation, or as monthly therapy for conditions like fibroids or endometriosis

In IVF, it’s often started in the mid-luteal phase (Day 21) of the previous cycle, followed by FSH/HMG stimulation after 14 days.

How Quickly Does It Work?

FOSTI-SURE DEPOT begins working within 7–10 days. Initially, you may notice a brief increase in hormone levels (called the flare effect), followed by a steady suppression.
In IVF, suppression is typically achieved within 2 weeks

In endometriosis or fibroid treatment, improvement in symptoms is seen within 2–3 weeks

Hormonal suppression continues for 28 days per dose

Side Effects of Leuprolide acetate depot injection

Because this injection temporarily suppresses estrogen and progesterone, some menopause-like side effects are common.
Common Side Effects:

• Hot flashes or night sweats
• Vaginal dryness
• Mood swings or irritability
• Decreased libido
• Headache or fatigue
• Mild bone density loss (with long-term use)

Serious but Rare Side Effects:

• Severe allergic reaction
• Joint or muscle pain
• Depression or severe mood changes
• Irregular bleeding
• Risk of bone thinning (osteoporosis) with prolonged use

To reduce side effects, your doctor may recommend “add-back therapy” with low-dose estrogen and progesterone.

Precautions Before Using Leuprolide acetate depot injection

Before starting this injection, tell your doctor if you have:

• History of osteoporosis or low bone density
• Unexplained vaginal bleeding
• History of depression or mental illness
• Severe liver or kidney problems
• Any known allergy to GnRH agonists
• This injection is not recommended during pregnancy or breastfeeding.

Can You Take Leuprolide acetate depot injection During Pregnancy?

No. Leuprolide acetate depot injection is contraindicated during pregnancy. You must avoid conception while on this injection, as it suppresses ovulation and alters the uterine lining.

If you become pregnant while taking Leuprolide acetate, inform your doctor immediately. It should not be used during or after embryo transfer in IVF cycles.

Storage Instructions

Store in refrigerator (2°C–8°C)

Do not freeze

Protect from direct sunlight and moisture

Use immediately after reconstitution

Keep out of reach of children

Why Choose FOSTI-SURE DEPOT by FertileSurePharma?

FertileSure Pharma offers evidence-based, clinically approved fertility and gynecology medicines trusted by specialists across India. With FOSTI-SURE DEPOT, you get:

• High-purity Leuprolide acetate
• Depot action for consistent monthly control
• WHO-GMP certified manufacturing
• Widely used in fertility clinics and gynecology hospitals
• Proven efficacy in IVF cycles, fibroids, and endometriosis

Conclusion

FOSTI-SURE DEPOT (Leuprolide acetate depot three.75mg injection) via FertileSure Pharma is a powerful tool in dealing with complicated reproductive and gynecological conditions. Whether you are present process IVF, coping with painful endometriosis, or making ready for fibroid surgical procedure, this GnRH agonist gives effective, long-acting hormone law.
When administered under expert steering, FOSTI-SURE DEPOT enables optimize your fertility remedy effects and improve high-quality of lifestyles.

FAQs

1. Can Leuprolide acetate depot injection delay my periods?

Yes. It suppresses ovulation and menstruation as part of its mechanism.

2. Is it painful to inject?

Mild discomfort may occur. It’s typically injected into the muscle by a trained nurse or doctor.

3. Can I conceive while using this medicine?

No. It suppresses fertility and should not be used if you are trying to conceive during treatment. It’s used before IVF, not during pregnancy.

4. How long can I use Leuprolide depot?

Usually up to 6 months, but longer use requires bone density monitoring.

5. What happens after I stop the injection?

Your periods and natural hormone cycles usually resume within 4–8 weeks after the final injection.